Two SUVs with some similarities, but otherwise different in most aspects such as the fuel economy, maximum occupancy, starting price, horsepower, ground shadow size, and height. First of all, the 2015 Toyota Sequoia is priced $7,840 lower compared to the base MSRP of the 2016 Lexus RX 450h. Also, the 2015 Sequoia has bigger and thirstier engine; the 2016 RX 450h gets 15 more mpg. In addition, the RX 450h is both slightly smaller and shorter than the Sequoia. And finally, the Toyota Sequoia seats three more passengers than the Lexus RX 450h. Among similarities is the body structure.