Two Sedans with more similarities, such as the body structure, market segment, ground shadow size, height, and maximum occupancy, than differences, like the powertrain, fuel economy, market segment, starting price, and horsepower. First of all, the 2016 Lexus IS 350 has bigger and thirstier engine; the 2016 Mercedes-Benz C-Class Hybrid gets 8.5 more mpg. Also, the 2016 IS 350 is priced $4,620 lower compared to the base MSRP of the 2016 C-Class Hybrid. Among similarities are the body structure, market segment, ground shadow size, height, and maximum occupancy.